Doubling down on the toxic and infect rats is a no-brainer for this deck, but remember that Karumonix, the Rat Kings toxic anthem stacks with other sources of poison
If you want him, you want him, and its probably for combos
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If a creature card was discarded this way, you create a 1/2 white Moogle creature token with lifelink

5-Color Niv-Mizzet by Michael Rapp 2 Paradise Druid 4 Sylvan Caryatid 1 Dreadbore 2 Abrupt Decay 4 Teferi, Time Raveler 1 Unmoored Ego 1 Deafening Clarion 3 Uro, Titan of Natures Wrath 1 Supreme Verdict 1 Utter End 1 Nahiri, the Harbinger 3 Siege Rhino 1 The Scarab God 1 Tolsimir, Friend to Wolves 4 Bring to Light 3 Niv-Mizzet Reborn 1 Cut // Ribbons 2 Botanical Sanctum 4 Fabled Passage 1 Forest 1 Godless Shrine 1 Island 2 Mana Confluence 1 Mountain 2 Opulent Palace 1 Overgrown Tomb 1 Plains 2 Sandsteppe Citadel 2 Spirebluff Canal 2 Stomping Ground 1 Swamp 2 Temple Garden 1 Watery Grave That makes my choice of flex slots: 1 Dreadbore 1 Unmoored Ego 1 Deafening Clarion 1 Uro, Titan of Natures Wrath 1 Nahiri, the Harbinger 1 Siege Rhino 1 The Scarab God 1 Tolsimir, Friend to Wolves 1 Cut // Ribbons As you can see, I went into the weekend ready for aggressively-slanted creature decks, like Mono-Red and Mono-Black

The Golden City of Orazca What makes The Golden City of Orazca such a great choice is that it gives players benefits for just playing Magic